Sun Laboratory
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The research at Liangliang Sun’s group at Michigan State University lies at the interface of analytical chemistry and developmental biology. We aim to develop novel analytical methodologies based on capillary electrophoresis-tandem mass spectrometry (CE-MS/MS) for comprehensive and quantitative bottom-up and top-down proteomics of various samples. We are also developing single-cell proteomics of zebrafish embryos and single blastomeres in the embryos during early embryogenesis.
Highlights
A new paper about top-down proteomics of cancer cells has been just published online in the journal Science Advances! It is an exciting start for us to study colorectal cancer using top-down proteomics and capillary electrophoresis mass spectrometry. It is fantastic teamwork from the Hummon group at OSU, the Liu group at Tulane University, and the Sun group at MSU.
A new paper about top-down proteomics of cancer cells has been just published online in the journal Science Advances! It is an exciting start for us to study colorectal cancer using top-down proteomics and capillary electrophoresis mass spectrometry. It is fantastic teamwork from the Hummon group at OSU, the Liu group at Tulane University, and the Sun group at MSU.
Our cIEF-MS method for high resolution characterization of mAb charge variant is featured on the front cover of Analytical Methods!
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Our Nano3 work for limited sample preparation is on Analytical Chemistry!
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Our work on ultralong capillary for CZE-MS/MS-based top-down proteomics is featured on the front cover of JASMS!
Research Interest
We are dedicated to implementing capillary electrophoresis mass spectrometry for comprehensive and quantitative bottom-up and top-down proteomics of zebrafish embryos and single blastomeres in the embryos during early embryogenesis. Our research will provide new insights into many important events during early vertebrate embryogenesis, e.g., early cellular differentiation and zygotic genome activation, thus leading to better understanding of birth defects that usually originate during early embryogenesis.
Summer school for capillary electrophoresis-mass spectrometry (CE-MS)
We will organize a summer school on CE-MS during July 22-24, 2024 for up to ten graduate students or postdocs who are using or plan to use CE-MS for peptides, proteins, or protein complexes in their research. During the three days of summer school, students will do experiments in my research lab at the Department of Chemistry of Michigan State University (East Lansing, Michigan) and learn how to make capillary coatings and how to set up CE-MS systems for bottom-up and top-down proteomics of simple and complex samples. We can offer up to $600 per student to cover some of the travel costs. The summer school is supported by the National Science Foundation (NSF). If you are interested, please send your brief CV to Drs. Guijie Zhu (zhuguiji@msu.edu) and Liangliang Sun (lsun@msu.edu) before May 31, 2024. You can learn more about our research through our publications (https://lnkd.in/eCTd4tRW)
Team
The Sun group is good at bringing together researchers from all around the world, who works towards a common goal of curiosity, intelligence and persistence.
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